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Sekcji Fitoterapii PTL
Sekcja Fitoterapii Polskiego Towarzystwa Lekarskiego

Izoflawony a utrata masy kostnej u kobiet w okresie pomenopauzalnym. I. Wpływ produktów i preparatów z soi na metabolizm kostny

© Borgis - Postepy Fitoterapii 3, s. 136-144
*Wiesław Maciej Kanadys1, Jan Oleszczuk2
Izoflawony a utrata masy kostnej u kobiet w okresie pomenopauzalnym. I. Wpływ produktów i preparatów z soi na metabolizm kostny
Isoflavones and bone loss in postmenopausal women. I. Effects of soy products and preparations on bone metabolism
1Poradnia Ginekologiczno-Położnicza Przychodni Specjalistycznej NZOZ Specjalistyka Czechów w Lublinie
Kierownik Przychodni: lek. med. Joanna Telecka
2Klinika Położnictwa i Perinatologii Akademii Medycznej im. prof. Feliksa Skubiszewskiego w Lublinie
Kierownik Kliniki: prof. dr hab. med. Jan Oleszczuk
Summary
The estrogen deficiency associated with menopause, in addition to aging processes, causes increased rate of bone turnover with adventage of resorption, and thereby accelerates bone loss. That is why many women, especially postmenopausal women, are exposed to developing osteoporosis, results in increased risk of fractures. Epidemiologic data shows that soy-rich diet has favourable impact on skeletal. Osteoprotective mechanism of action of soy is not fully clarified. Although results of both in vivo and in vitro studies indicate that isoflavones may affect bone cell activity through estrogen receptor-mediated, modulates the osteoprotegerin (OPG)-receptor activator of nuclear factor κB ligand (RANKL) system, and stimulates production of insulinlike growth factor 1 (IGF-1). This paper reviews the scientific literature regarding the effects of soy products and preparations on the skeleton. Twenty four randomized, controlled, clinical researches formed the basis for this review. Some studies revealed that soy isoflavones and/or soy protein intake had a modest effect on bone mineral density (BMD) and on levels of biochemical markers of bone turnover (of formation and of resorption), but such effects were not observed in other studies. Divergence among results of separates clinical trials caused that effect of soy on bone remodelling is still unclear. Short-term use of dietary or supplemental isoflavones may have a limited role in prevention of bone loss. Large, long duration, multicenter, randomized controlled trial in a large number of women is needed to answer these questions.
Key words: soy, isoflavones, isolated soy protein, bone mineral density (bmd), biochemical markers of bone remodelling, skeletal, randomized controlled trial
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otrzymano/received: 2007-08-15
zaakceptowano/accepted: 2007-09-20

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*Wiesław M. Kanadys
ul. Leszetyckiego 6/49, 20-861 Lublin
tel.: (0-81) 741-26-52
e-mail: wieslaw.kanadys@wp.pl
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