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Naryngenina i jej pochodne – flawanony o wielokierunkowej aktywności farmakologicznej*

© Borgis - Postepy Fitoterapii 1, s. 16-22
*Loretta Pobłocka-Olech, Karina Marcinkowska, Mirosława Krauze-Baranowska
Naryngenina i jej pochodne – flawanony o wielokierunkowej aktywności farmakologicznej*
Naringenin and its derivatives – flavanones with multidirectional pharmacological activity
Katedra i Zakład Farmakognozji z Ogrodem Roślin Leczniczych Akademii Medycznej w Gdańsku
Kierownik Katedry i Zakładu: prof. dr hab. Wojciech Cisowski
Summary
Naringenin and its derivatives are constituents of some fruits (grapefruits, oranges, mandarins) and herbal medicinals (Salicis cortex). Over last years pharmacological activity of flavanones was extensively investigated – including naringenin and its prenyl derivatives (6-PN and 8-PN). The article presents the results of research on estrogenic, antiarteriosclerotic, antiulcer, antioxidant and neuroprotective activities of these compounds
Key words: naringenin, prenyl derivatives, flavanones, pharmacological activity
Piśmiennictwo
1. Iwashina T.: The structure and distribution of the flavonoids in plants. J. Plant Res. 2000, 113, 287. 2. Tomas-Barberan F.A., Clifford M.N.: Flavanones, chalcones and dihydrochalcones – nature, occurence and dietary burden. J. Sci. Food Agric. 2000, 80, 1073. 3. Erlund I.: Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability and epidemiology. Nutr. Res. 2004, 24, 851. 4. Cos P. et al: Phytoestrogens: Recent developments. Planta Med. 2003, 69, 589. 5. Le Bail J.C. et al: Chalcones are potent inhibitors of aromatase and 17b-hydroxysteroid dehydrogenase activities. Life Sci. 2001, 68, 751. 6. Miksicek R.J.: Commonly occuring plant flavonoids have estrogenic activity. Mol. Pharmacol. 1993, 44, 37. 7. So F.V. et al: Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr. Cancer 1996, 26, 167. 8. Totta P. et al: Mechanisms of naringenin-induced apoptotic cascade in cancer cells: Involvement of estrogen receptor a and b signalling. IUBMB Life 2004, 56, 491. 9. Zierau O. et al: Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-Dimethylallyl)naringenin and 8-Prenylnaringenin. Planta Med. 2002, 68, 449. 10. Zierau O. et al: Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems. Biochem. Biophys. Res. Commun. 2005, 326, 909. 11. Zierau O. et al: Antiandrogenic activity of the phytoestrogens naringenin, 6-(1,1-Dimethylallyl)naringenin and 8-Prenylnaringenin. Planta Med. 2003, 69, 856. 12. Borradaile N.M. et al: Inhibition of hepatocyte apoB secretion by naringenin: Enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters. J. Lipid Res. 2002, 43, 1544. 13. Lee M.K. et al: Supplementation of naringenin and its synthetic derivative alters antioxidant enzyme activities of erythrocyte and liver in high cholesterol-fed rats. Bioorg. Med. Chem. 2002, 10, 2239. 14. Santos K.F.R. et al: Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations. Pharmacol. Res. 1999, 40, 493. 15. Bae E.A., Han M.J., Kim D.H.: In vitro anti- Helicobacter pylori activity of some flavonoids and their metabolites. Planta Med. 1999, 65, 442. 16. Martin M.J., Motilva V., De la Lastra A.: Quercetin and naringenin: effects on ulcer formation and gastric secretion in rats. Phytother. Res. 1993, 7, 150. 17. Shin J.E. et al: In vitro inhibitory effect of flavonoids on growth, infection and vacuolation of Helicobacter pylori. Planta Med. 2005, 71, 197. 18. Hammad H.M., Shtaywy A.H.: Pharmacological effects of selected flavonoids on rat isolated ileum: Structure – activity relationship. Gen. Pharmac. 1997, 28, 767. 19. Orallo F. et al: Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (±)-naringenin. Planta Med. 2005, 71, 99. 20. Bonina F. et al: Flavonoids as potential protective agents against photo-oxidative skin damage. Int. J. Pharm. 1996, 145, 87. 21. Saija A. et al: Influence of different penetration enhancers on in vitro skin permeation and in vivo photoprotective effect of flavonoids. Int. J. Pharm. 1998, 175, 85. 22. Miligan S. R. et al: The endocrine activities of 8-prenylnaringenin and related hop ( Humulus lupulus L.) flavonoids. J. Clin. Endocr. Metab. 2000, 85, 4912. 23. Kitaoka M. et al: Prenylflavonoids: A new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure – activity relationship. Planta Med. 2002, 68, 449. 24. Miligan S. R. et al: Identification of a potent phytoestrogen in hops ( Humulus lupulus L.) and beer. J. Clin. Endocr. Metab. 1999, 83, 2249. 25. Saija A. et al: Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radic. Biol. Med. 1995, 19, 481. 26. Mira L. et al: Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity. Free Radic. Res. 2002, 36, 1199. 27. Edwards D.J., Bernier S.M.: Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice. Life Sci. 1996, 59, 1025. 28. Ho P.C. et al: Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharm. Acta Helv. 2000, 74, 379. 29. Heo H.J. et al: Effect of antioxidant flavanone, naringenin, from Citrus junos on neuroprotection. J. Agric. Food Chem. 2004, 52, 1520. 30. Chiou G.C.Y., Xu X.-R.: Effects of some natural flavonoids on retinal function recovery after ischemic insult in the rat. J. Ocul. Pharmacol. Ther. 2004, 20, 107. 31. Park Y.H., Chiou G.C.Y.: Structure-activity relationship (SAR) between some natural flavonoids and ocular blood flow in the rabbit. J. Ocul. Pharmacol.Ther. 2004, 20, 35.

otrzymano/received: 2005-02-14
zaakceptowano/accepted: 2005-10-21

Adres/address:
*Loretta Pobłocka-Olech
Katedra i Zakład Farmakognozji AM w Gdańsku
Al. Gen. J. Hallera 107, 80-416 Gdańsk
tel. (0-58) 349-31-60, 349-31-61
e-mail: weis@farmacja.amg.gd.pl

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