© Borgis - Postepy Fitoterapii 1, s. 24-38
*Natalia Wszelaki
Hamowanie aktywności acetylocholinoesterazy i butyrylocholinoesterazy przez surowce roślinne i ich substancje czynne
PLANTS AS A SOURCE OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORS
Institut für Pharmazie, Pharmazeutische Biologie, Freie Universität Berlin
Kierownik grupy badawczej: prof. Matthias F. Melzig
Summary
Acetylcholinesterase (AChE) inhibitors are widely used as a drug for the symptomatic treatment of Alzheimer´s disease (AD) – a progressive, neurodegenerative disorder associated with a decline in cognitive abilities. In the treatment of AD only following AChE inhibitors are used: donepezil, rivastigmine and galantamine. Since they have many unpleasant side effects, new substances are being investigated. Herbal extracts seem to be a significant source of new potential AChE and butyrylcholinesterase (BuChE) inhibitors, like hupercine A isolated from club moss (Huperzia serrata). The biologically active plant-derived substances come from different class of compounds and they are characterized by the diversity of structure. Majority of the bioactive substances are indol, steroids, piperidine, Amaryllidaceae type alkaloids, phenylpropanoids (furanocoumarins, xantons, and flavonoids) and terpenoids (diterpenes). There are many reports that not only pure isolated substances could be applied but also standardized plant extracts (Ginkgo biloba or Salvia officinalis), since they have other constituents also helpful in the therapy (antioxidants). The aim of this article is to collect all the informations from the literature about plants that have been tested for AChE or/and BuChE inhibitory activity and which plants or the constituents remarkable are.
Key words: plants, alzheimer´s disease, acetylcholine, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, cholinesterase
Piśmiennictwo
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otrzymano/received: 2009-02-05
zaakceptowano/accepted: 2009-02-15
Adres/address:
* Natalia Wszelaki
Institut für Pharmazie, Pharmazeutische Biologie
Freie Universität Berlin
Königin Luise Str. 2+4, 14195 Berlin, Niemcy
tel. (+49)-0175-357-3559
e-mail: natala345@yahoo.co.uk