» Genetyczne i cytokinowe wyznaczniki odpowiedzi na szczepionkę BCG u studentów Uniwersytetu Łódzkiego

*Wiesława Rudnicka, Piotr Szpakowski, Marcin Włodarczyk, Magdalena Kowalewicz-Kulbat, Magdalena Druszczyńska, Marek Fol

Genetyczne i cytokinowe wyznaczniki odpowiedzi na szczepionkę BCG u studentów Uniwersytetu Łódzkiego

Genetic and cytokine markers of immune response to the BCG vaccine in the population of Łódź University

Katedra Immunologii i Biologii Infekcyjnej, Instytut Mikrobiologii Biotechnologii i Immunologii, Uniwersytet Łódzki
Kierownik Katedry: prof. dr hab. Wiesława Rudnicka

Summary

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Piśmiennictwo

1. Mustafa A.S. Development of new vaccines and diagnostic reagents against tuberculosis. Mol. Immunol. 2002; 39: 113-119. 2. MittrŘcker H-W. et al. Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis. Proc. Natl. Acad. Sci. USA. 2007; 104: 12434-12439. 3. Reece ST and Kaufmann SH. Rational design of vaccines against tuberculosis directed by basic immunology. Int. J. Med. Microbiol. 2008;298:143-150. 4. WHO Global Tuberculosis Control Surveillance, Planning, Finansing. WHO Report 2004. Geneva, Switzerland. 5. Rudnicka W i Rudnicka K. 60 lat szczepień BCG. Osiągnięcia, przegrane i nadzieje - nowe szczepionki przeciwgručlicze w programach klinicznych. Post. Mikrob. 2008;47:379-385. 6. Agger EM et al. Protective immunity to tuberculosis with Ag85B-ESAT-6 in synthetic cationic adiuvant system IC31. Vaccine. 2006;24:54-52. 7. Hawkridge T et al. Safety and immunoigenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa. J. Infect. Dis. 2008;15:544-552. 8. Rudnicka W. Molekularne mechanizmy odporności na gručlicę. Post. Mikrobiol. 2004; 43: 107-127. 9. Finan C. et al. Natural variation in immune responses to neonatal Mycobacterium bovis Bacillus Calmette-Guerin (BCG) vaccination in a cohort of Gambian infants. PLOS ONE. 2008; 3: e3485. 10. Takeda K and Akira S. Toll-like receptors in innate immunity. Int. Immunol. 2005;17:1-14. 11. Reiling N. et al. Cutting edge: Toll-like receptor (TLR)2- and TLR4- mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol. 2002; 169: 3480-3484. 12. Strapagiel D et al. Monocyte response receptors in BCG driven delayed type hypersensitivity to tuberculin. Folia Histochem. Cytobiol. 2008;46:353-359. 13. Druszczyńska M. et al. Tuberculosis bacilli still posing a threat. Polymorphism of genes regulating anti-mycobacterial properties of macrophages. Pol. J. Microbiol. 2006; 55: 7-12. 14. Pacheco E. et al. CD14 gene promoter polymorphism in different forms of tuberculosis. FEMS Immunol. Med. Microbiol. 2004; 40:207-213. 15. Rosas-Taraco A.G. et al. CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. J Infect. Dis. 2007; 196: 1698-1706. 16. Athman R., Philpott D. Innate immunity via Toll-like receptors and Nod Proteins. Curr. Opin. Microbiol. 2004; 7: 25-32. 17. North R.J. et al. Significance of antimycobacterial gene, Nramp1, in resistance to virulent Mycobacterium tuberculosis infection. Res. Immunol. 1996;147:493-499. 18. Gomez MA, Li S, Tremblay ML, Olivier M. NRAMP-1 expression modulate protein-tyrosine phosphate activity In macrophages. Impact on host cell signalling and function. J. Biol. Chem. 282, 2007, 36190-36198. 19. Selvaraj P. Et al. Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with live Mycobacterium tuberculosis in pulmonary tuberculosis. FEMS Immunol. Med. Microbiol. 2006;46:433-437. 20. Awomoyi A. Et al. Interleukin-10 polymorphism in SLC11A1 and susceptibility to tuberculosis. J. Infect. Dis. 2002; 186: 1808-1814. 21. Stenger S. Immunological control of tuberculosis: role of tumour necrosis factor and more. Ann. Rheum. Dis. 2005; 64: 24-28. 22. Biet F. et al. Mycobacterium bovis BCG producing IL-18 increases antigen-specific gamma interferon production in mice. Infect. Immun. 2002; 70: 6549-6557. 23. Gracie J.A. et al. Interleukin-18. J. Leukoc. Biol. 2003; 73: 213-224. 24. Tominaga K. et al. IL-12 synergizes with IL-18 or IL-1b for IFN-γ production from human T cells. Intern. Immunol. 2000; 12: 151-160. 25. Paziak-Domańska B. et al. The lack of relationship between serum content of MBL, sCD14, anti-PPD and anti-Hsp65 IgG and ingestion of Mycobacterium bovis BCG bacilli by phagocytes. Arch. Immunol. Ther. Exp. 2002; 50: 337-344. 26. Kowalewicz - Kulbat M et al. Naive helper T cells from BCG-vaccinated volunteers produce IFN-γ and IL-5 to mycobacterial antigen-pulsed dendritic cells. Folia Histochem. Cytobiol. 2008; 46: 5-9.

otrzymano/received: 2009-03-10
zaakceptowano/accepted: 2009-04-02

Adres/address:
*Wiesława Rudnicka
Katedra Immunologii i Biologii Infekcyjnej
Instytut Mikrobiologii Biotechnologii i Immunologii, Uniwersytet Łódzki
ul. Banacha 12/16, 90-237 Łódź
tel.: (0-42) 635-44-72,
e-mail: rudw@biol.uni.lodz.pl

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