current
issue
2/2013

Nowe nieznane funkcje witaminy D

© Borgis - Medycyna Rodzinna 2, p. 34-47
Justyna Kosińska1, Katarzyna Billing-Marczak1, *Marcin Krotkiewski2
Nowe nieznane funkcje witaminy D
NEW UNKNOWN FUNCTIONS OF VITAMIN D
1 Dział Badań i Rozwoju Nowych Produktów, Biotech-Varsovia Sp. z o.o. – Sp. K. w Warszawie Dyrektor Działu: dr n. biol. Katarzyna Billing-Marczak 2 The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Göteborg, Sweden
Summary
Vitamin D together with vitamin K contribute to the absorption of calcium and mineralization of bones. Recent epidemiological studies are indicating several nonskeletal effects of vitamin D. Negative correlations with vitamin D serum levels were found for hypertension, diabetes type 1 and 2, obesity, metabolic syndrome, chronic inflammatory conditions and different forms of cancers. In particular incidence of colon and anal cancer, cancer of prostate, ovarian and uterus cancer as well as breast cancer and Hodgkin lymphoma is negatively correlated with serum concentration of vitamin D. Multiorgans effects of vitamin D depend on the presence in different tissues of specific receptors (VDR). Vitamin D3 combines with VDR and subsequently with RXR (Retinoid X Receptor). The complex vitamin D – VDR – RXR is later functioning as typical transcription factor activating specific sequences in promoters of several genes – VDRE (Vitamin D Response Elements) – expressing different proteins. This mechanism responds for the increased synthesis of and sensitivity to insulin. Vitamin D is inhibiting the activity of transcription factor NFkB and decreasing the production of proinflammatory cytokines. The immunomodulating effect of vitamin D is also expressed as lower incidence of virus and bacterial infections. Vitamin D is slowing down the shortening of telomeres indicating possible influence on aging and longevity. Supplementation with vitamin D is highly recommended particularly for older people. Recommended daily doses should be strongly increased.
Key words: vitamin D, obesity, hypertension, diabetes
Pi¶miennictwo
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otrzymano/received: 2008-05-26
zaakceptowano/accepted: 2008-06-12

Adres/address:
*Marcin Krotkiewski Biotech-Varsovia Sp. z o.o. – Spółka komandytowa ul. Domaniewska 47, 02-672 Warszawa e-mail: m.krotkiewski@nestenborg.net

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