© Borgis - Medycyna Rodzinna 2, p. 50-53
Joanna Jońska-Gmyrek1, Bogusław Lindner1, Leszek Jarosław Gmyrek2, Jagna Staniaszek1, Ryszard Krynicki2, Norbert Piotrkowicz3, Mariusz Bidziński2, Krzysztof Bujko1
Zasady postępowania diagnostycznego i terapeutycznego w raku pochwy
The diagnostic and therapeutic principles in vaginal cancer
1 Zakład Teleradioterapii Centrum Onkologii-Instytutu im. Marii Skłodowskiej-Curie w Warszawie
Kierownik: doc. dr hab. Krzysztof Bujko
2 Klinika Nowotworów Narz±dów Płciowych Kobiecych Centrum Onkologii-Instytutu im. Marii Skłodowskiej-Curie w Warszawie
Kierownik: doc. dr hab. Mariusz Bidziński
3 Zakład Brachyterapii Centrum Onkologii-Instytutu im. Marii Skłodowskiej-Curie w Warszawie
Kierownik: dr n. med. Jarosław Łyczek
Summary
Carcinomas of the vagina are uncommon tumors, comprising 1% to 2% of all gynecologic malignancies (1, 4, 8, 13). Vaginal cancer has a peak incidence between 60 and 70 years of age, however, cancer developed on the base of HPV infection is noted in younger age groups. About 10% of patients are younger than 50 years old (5).Radiation therapy is the standard treatment for patients with vaginal carcinoma, however, in early, selected cases, surgical treatment is performed (13).
Regardless of the treatment modality, the recognized prognostic factors in vaginal cancer are: the stage of the disease (8, 9), the location of the primary lesion, age (6), the differentiation and histopatological type of the tumor, which sometimes are the subject of discussion (8, 14).
The 5-year survival for patients with vaginal cancer, in respect of the stage of the disease, according to the literature data, are: I – 73-82%, II – 53-58%, III, IV – 36% (4, 9, 12).
Key words: vaginal cancer, diagnostics, treatment, surgery, radiotherapy
Pi¶miennictwo
1. Kulikowski M., Terlikowski S.J.: Nowotwory pochwy w: Ginekologia Onkologiczna. Pod red. J. Markowskiej; 2006, 41: 494. Urban & Partner. 2.Fu Y.S., Reagan J.W.: Pathology of the uterine cervix, vagina and vulva. W.B. Saunders. Philadelphia 2002, 232. 3.Kurman R.J., Norris H.J., Wilkinson E.J.: Atlas of tumor pathology. Tumors of the cervix, vagina and vulva. Armed Forces Institute of Pathology, Washington 1992, 141. 4.Creasman W.T., Philips J.L., Menck H.R.: The National Cancer database report on cancer of the vagina. Cancer 1998, 83: 1033-1040. 5.Di Domenico.: A primary vaginal squamous cell carcinoma in the young patients. Gynecol. Oncol., 1989, 35: 185-187. 6.Urbanski K., i wsp.: Primary invasive vaginal carcinoma treated with radiotherapy: analysis of prognostic factors. Gynecol. Oncol., 1996, 60: 16-21. 7.Samant R,. Lau B., Le T., i wsp.: Primary vaginal cancer treated with concurrent chemoradiation using cis-platinum. Int. J. Radiat. Oncol. Biol. Phys., 2007 May 16. 8.Fujimura M.: Prognostic factors of vaginal cancer. Gan To Kagaku Ryoho 2006, 33, 13: 1998-2001. 9.Hellman K., Lundell M,. Silfversward C., i wsp.: Clinical and histopathologic factors related to prognosis in primary squamous cell carcinoma of the vagina. Int. J. Gynecol. Cancer 2006, 16, 3: 1201-11. 10.Samant R., Tam T., Dahrouge S., i wsp.: Radiotherapy for the treatment of primary vaginal cancer. Radiother Oncol., 2005, 77, 2: 133-6. 11.Frank S.J., Jhingran A., Levenback C., i wsp.: Definitive radiation therapy for squamous cell carcinoma of the vagina. Int. J. Radiat. Oncol. Biol. Phys., 2005, 62, 1: 138-147. 12.Davis K.P., Stanhope C.R., Garton G.R., i wsp.: Invasive vaginal carcinoma: analysis of early stage disease. Gynecol. Oncol., 1991, 42, 2: 131-136.13. Grisby P.W.: Vaginal cancer. Curr. Treat. Options Oncol., 2002, 3, 2: 125-130. 14.Perez C.A., Grisby P.W., Garipagaoglu M., i wsp.: Factors affecting long-term outcome of irradiation In carcinoma of the vagina. Int. J. Radiat. Oncol. Biol. Phys., 1999, 44, 1: 37-45. 15.Cardenes H.R., Roth L.M., Mc Guire W.P.: Vagina. In: Principles and Practice of Gynecologic Oncology. W.J Hoskins, C.A Perez i wsp. Lippincott Wiliams&Wilkins. 4-th ed, 2005, 21: 714.
otrzymano/received: 2007-06-11
zaakceptowano/accepted: 2007-06-15
Adres/address:
*Joanna Jońska-Gmyrek
Zakład Teleradioterapii Centrum Onkologii – Instytut im. M. Skłodowskiej-Curie
ul. Roentgena 5, 02-781 Warszawa
tel. (0-22) 546-29-11
e-mail: jonska@wp.pl
